MOLECULAR PATHOGENESIS OF EBV SUSCEPTIBILITY IN XLP AS REVEALED BY ANALYSIS OF FEMALE CARRIERS WITH HETEROZYGOUS EXPRESSION OF SAP.

Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.

X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP.SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors.A defining feature of XLP is exquisite sensitivity to infection with EBV, a B-lymphotropic virus, but not other viruses.Although previous stu

read more




Study protocol: a mixed-methods study to evaluate which health visiting models in England are most promising for mitigating the harms of adverse childhood experiences

Introduction Exposure to adverse childhood experiences (ACEs) is associated with poorer health outcomes throughout life.In England, health visiting is a long-standing, nationally implemented service that aims to prevent and mitigate the impact of adversity in early childhood, including for children exposed to ACEs.A range of hydrangea red sensation

read more